A New Framework to Implement Model-Informed Dosing in Clinical Guidelines: Piperacillin and Amikacin as Proof of Concept

Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guideline...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Hartman, Stan J. F., Swaving, Joost G. E., van Beek, Stijn W., van Groen, Bianca D., de Hoop, Marika, van der Zanden, Tjitske M., ter Heine, Rob, de Wildt, Saskia N.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2020
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772249/
https://ncbi.nlm.nih.gov/pubmed/33390970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.592204
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