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The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for the production of colibactin, we found that a...

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Bibliografische gegevens
Gepubliceerd in:mSphere
Hoofdauteurs: Tang-Fichaux, Min, Chagneau, Camille V., Bossuet-Greif, Nadège, Nougayrède, Jean-Philippe, Oswald, Éric, Branchu, Priscilla
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7771237/
https://ncbi.nlm.nih.gov/pubmed/33328353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.01195-20
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