Identifying and Tracking Low-Frequency Virus-Specific TCR Clonotypes Using High-Throughput Sequencing

Tracking antigen-specific T cell responses over time within individuals is difficult because of lack of knowledge of antigen-specific TCR sequences, limitations in sample size, and assay sensitivities. We hypothesized that analyses of high-throughput sequencing of TCR clonotypes could provide functi...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Wolf, Kyle, Hether, Tyler, Gilchuk, Pavlo, Kumar, Amrendra, Rajeh, Ahmad, Schiebout, Courtney, Maybruck, Julie, Buller, R. Mark, Ahn, Tae-Hyuk, Joyce, Sebastian, DiPaolo, Richard J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Author(s). 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7770954/
https://ncbi.nlm.nih.gov/pubmed/30485806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.009
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