Tracking TCRβ Sequence Clonotype Expansions during Antiviral Therapy Using High-Throughput Sequencing of the Hypervariable Region

To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses during chronic infection and antiviral therapy. Co...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Robinson, Mark W., Hughes, Joseph, Wilkie, Gavin S., Swann, Rachael, Barclay, Stephen T., Mills, Peter R., Patel, Arvind H., Thomson, Emma C., McLauchlan, John
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820669/
https://ncbi.nlm.nih.gov/pubmed/27092143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00131
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