The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central role of Tfh cells in vaccine responses, there is currently no validated way to enhance their differentiation...

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Vydáno v:J Exp Med
Hlavní autoři: Hill, Danika L., Pierson, Wim, Bolland, Daniel J., Mkindi, Catherine, Carr, Edward J., Wang, Jiong, Houard, Sophie, Wingett, Steven W., Audran, Regine, Wallin, Elizabeth F., Jongo, Said A., Kamaka, Kassim, Zand, Martin, Spertini, Francois, Daubenberger, Claudia, Corcoran, Anne E., Linterman, Michelle A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683991/
https://ncbi.nlm.nih.gov/pubmed/31175140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190301
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