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Structure of an affinity-matured inhibitory recombinant Fab against urokinase plasminogen activator reveals basis of potency and specificity
Affinity maturation of U33, a recombinant Fab inhibitor of uPA, was used to improve the affinity and the inhibitory effect compared to the parental Fab. Arginine scanning of the six CDR loops of U33 was done to identify initial binding determinants since uPA prefers arginine in its primary substrate...
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| Udgivet i: | Biochim Biophys Acta Proteins Proteom |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7770097/ https://ncbi.nlm.nih.gov/pubmed/33221341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2020.140562 |
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