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Affinity maturation of a portable Fab–RNA module for chaperone-assisted RNA crystallography
Antibody fragments such as Fabs possess properties that can enhance protein and RNA crystallization and therefore can facilitate macromolecular structure determination. In particular, Fab BL3–6 binds to an AAACA RNA pentaloop closed by a GC pair with ∼100 nM affinity. The Fab and hairpin have served...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5861428/ https://ncbi.nlm.nih.gov/pubmed/29309709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1292 |
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