HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation

Gene expression programs determine cell fate in embryonic development and their dysregulation results in disease. Transcription factors (TFs) control gene expression by binding to enhancers, but how TFs select and activate their target enhancers is still unclear. HOX TFs share conserved homeodomains...

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Publicado en:PLoS Genet
Main Authors: Bridoux, Laure, Zarrineh, Peyman, Mallen, Joshua, Phuycharoen, Mike, Latorre, Victor, Ladam, Frank, Losa, Marta, Baker, Syed Murtuza, Sagerstrom, Charles, Mace, Kimberly A., Rattray, Magnus, Bobola, Nicoletta
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769617/
https://ncbi.nlm.nih.gov/pubmed/33315856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009162
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