Proteostasis is adaptive: Balancing chaperone holdases against foldases

Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to different conditions? Here, we explore a biophysical cost-benefit principle, namely that the cell should keep its proteome as folded as possible at t...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: de Graff, Adam MR, Mosedale, David E., Sharp, Tilly, Dill, Ken A., Grainger, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769611/
https://ncbi.nlm.nih.gov/pubmed/33315891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008460
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