Dissociating antibacterial from ototoxic effects of gentamicin C-subtypes

Gentamicin is a potent broad-spectrum aminoglycoside antibiotic whose use is hampered by ototoxic side-effects. Hospital gentamicin is a mixture of five gentamicin C-subtypes and several impurities of various ranges of nonexact concentrations. We developed a purification strategy enabling assaying o...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: O’Sullivan, Mary E., Song, Yohan, Greenhouse, Robert, Lin, Randy, Perez, Adela, Atkinson, Patrick J., MacDonald, Jacob P., Siddiqui, Zehra, Lagasca, Dennis, Comstock, Kate, Huth, Markus E., Cheng, Alan G., Ricci, Anthony J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768767/
https://ncbi.nlm.nih.gov/pubmed/33288712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013065117
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