Multicenter, Randomized, Phase III Trial of Neoadjuvant Chemoradiation With Capecitabine and Irinotecan Guided by UGT1A1 Status in Patients With Locally Advanced Rectal Cancer

Differentiating the irinotecan dose on the basis of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype improves the pathologic complete response (pCR) rate. In this study, we further investigated preoperative irinotecan combined with capecitabine-based chemoradiotherapy for locall...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Zhu, Ji, Liu, Anwen, Sun, Xinchen, Liu, Luying, Zhu, Yaqun, Zhang, Tao, Jia, Jianhui, Tan, Shisheng, Wu, Junxin, Wang, Xin, Zhou, Juying, Yang, Jialin, Zhang, Chen, Zhang, Hongyan, Zhao, Yuanyuan, Cai, Gang, Zhang, Wei, Xia, Fan, Wan, Juefeng, Zhang, Hui, Shen, Lijun, Cai, SanJun, Zhang, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768334/
https://ncbi.nlm.nih.gov/pubmed/33119477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.20.01932
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