Neoadjuvant chemoradiotherapy with capecitabine and irinotecan guided by UGT1A1 status in patients with locally advanced rectal cancer: 5‐year update of the CinClare trial

Abstract Background The optimal regimen and chemotherapy intensity are still under investigation for neoadjuvant treatment of locally advanced rectal cancer (LARC). The CinClare trial has demonstrated improved pathologic complete response (pCR) with the addition of irinotecan to neoadjuvant chemorad...

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Hlavní autoři:	Zhen Zhang, Xinchen Sun, Anwen Liu, Yaqun Zhu, Tao Zhang, Luying Liu, Jianhui Jia, Shisheng Tan, Junxin Wu, Xin Wang, Juying Zhou, Jialin Yang, Chen Zhang, Hongyan Zhang, Xinjia He, Gang Cai, Chengyi Huang, Fan Xia, Juefeng Wan, Hui Zhang, Lijun Shen, Ling Wang, Wei Zhang, Sanjun Cai, Ji Zhu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-11-01
Edice:	Cancer Communications
Témata:	antineoplastic combined chemotherapy protocols capecitabine capecitabine‐irinotecan combination irinotecan neoadjuvant therapy Rectal neoplasms
On-line přístup:	https://doi.org/10.1002/cac2.70058
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