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IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling
Immunomodulatory imide drugs (IMiDs) bind CRBN, a substrate receptor of the Cul4A E3 ligase complex, enabling the recruitment of neo-substrates, such as CK1α, and their degradation via the ubiquitinproteasome system. Here, we report FAM83F as such a neo-substrate. The eight FAM83 proteins (A-H) inte...
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| 發表在: | Life Sci Alliance |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Life Science Alliance LLC
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7768194/ https://ncbi.nlm.nih.gov/pubmed/33361334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000804 |
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