The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration

Sorsby Fundus Dystrophy (SFD) is a rare inherited autosomal dominant macular degeneration caused by specific mutations in TIMP3. Patients with SFD present with pathophysiology similar to the more common Age-related Macular Degeneration (AMD) and loss of vision due to both choroidal neovascularizatio...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Wolk, Alyson, Upadhyay, Mala, Ali, Mariya, Suh, Jason, Stoehr, Heidi, Bonilha, Vera L., Anand-Apte, Bela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767753/
https://ncbi.nlm.nih.gov/pubmed/32828705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101681
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