Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Choroidal neovascularization (CNV) leads to loss of vision in patients with Sorsby Fundus Dystrophy (SFD), an inherited, macular degenerative disorder, caused by mutations in the Tissue Inhibitor of Metalloproteinase-3 (TIMP3) gene. SFD closely resembles age-related macular degeneration (AMD), which...

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Publicado no:Sci Rep
Main Authors: Qi, Jian Hua, Bell, Brent, Singh, Rupesh, Batoki, Julia, Wolk, Alyson, Cutler, Alecia, Prayson, Nicholas, Ali, Mariya, Stoehr, Heidi, Anand-Apte, Bela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874529/
https://ncbi.nlm.nih.gov/pubmed/31757977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53433-6
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