Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism

Choroidal neovascularization (CNV) leads to loss of vision in patients with Sorsby Fundus Dystrophy (SFD), an inherited, macular degenerative disorder, caused by mutations in the Tissue Inhibitor of Metalloproteinase-3 (TIMP3) gene. SFD closely resembles age-related macular degeneration (AMD), which...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Qi, Jian Hua, Bell, Brent, Singh, Rupesh, Batoki, Julia, Wolk, Alyson, Cutler, Alecia, Prayson, Nicholas, Ali, Mariya, Stoehr, Heidi, Anand-Apte, Bela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874529/
https://ncbi.nlm.nih.gov/pubmed/31757977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-53433-6
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