Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice

Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow (BM) cells regulates atherogenesis by modulating inflammation an...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Saaoud, Fatma, Wang, Junfeng, Iwanowycz, Stephen, Wang, Yuzhen, Altomare, Diego, Shao, Ying, Liu, Jianguo, Blackshear, Perry J., Lessner, Susan M., Murphy, E. Angela, Wang, Hong, Yang, Xiaofeng, Fan, Daping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
Onderwerpen:
Articles from the Special Issue on Redox Signalling and Cardiovascular Disease; Edited by Christopher Kevil and Yabing Chen
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767740/
https://ncbi.nlm.nih.gov/pubmed/32591281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101609
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