Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

Chalcones are responsible for biological activity throughout fruits, vegetables, and medicinal plants in preventing and treating a variety of inflammation-related diseases. However, their structure-activity relationship (SAR) in inhibiting inflammasome activation has not been explored. We synthesize...

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Publicado no:Molecules
Main Authors: Leu, Wohn-Jenn, Chu, Jung-Chun, Hsu, Jui-Ling, Du, Chi-Min, Jiang, Yi-Huei, Hsu, Lih-Ching, Huang, Wei-Jan, Guh, Jih-Hwa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767297/
https://ncbi.nlm.nih.gov/pubmed/33339319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25245960
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