Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

Alkaline phosphatase (AP) activity is highly upregulated in plasma during liver diseases. Previously, we demonstrated that AP is able to detoxify lipopolysaccharide (LPS) by dephosphorylating its lipid A moiety. Because a role of gut-derived LPS in liver fibrogenesis has become evident, we now exami...

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Bibliografiska uppgifter
I publikationen:Cells
Huvudupphovsmän: Schippers, Marlies, Post, Eduard, Eichhorn, Ilse, Langeland, Jitske, Beljaars, Leonie, Malo, Madhu S., Hodin, Richard A., Millán, José Luis, Popov, Yury, Schuppan, Detlef, Poelstra, Klaas
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766276/
https://ncbi.nlm.nih.gov/pubmed/33348845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9122708
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