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EGFR-Binding Peptides: From Computational Design towards Tumor-Targeting of Adeno-Associated Virus Capsids

The epidermal growth factor receptor (EGFR) plays a central role in the progression of many solid tumors. We used this validated target to analyze the de novo design of EGFR-binding peptides and their application for the delivery of complex payloads via rational design of a viral vector. Peptides we...

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Publicat a:Int J Mol Sci
Autors principals: Feiner, Rebecca C., Kemker, Isabell, Krutzke, Lea, Allmendinger, Ellen, Mandell, Daniel J., Sewald, Norbert, Kochanek, Stefan, Müller, Kristian M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7765298/
https://ncbi.nlm.nih.gov/pubmed/33333826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249535
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