Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice

BACKGROUND: NEO212 is a novel small-molecule anticancer agent that was generated by covalent conjugation of the natural monoterpene perillyl alcohol (POH) to the alkylating agent temozolomide (TMZ). It is undergoing preclinical development as a therapeutic for brain-localized malignancies. The aim o...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Cho, Hee-Yeon, Swenson, Steve, Thein, Thu Zan, Wang, Weijun, Wijeratne, Neloni R, Marín-Ramos, Nagore I, Katz, Jonathan E, Hofman, Florence M, Schönthal, Axel H, Chen, Thomas C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7764505/
https://ncbi.nlm.nih.gov/pubmed/33392507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa160
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