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Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A(2) (sPLA(2)) Decrease Cell Viability and Induce Apoptosis in Metastatic Triple-Negative Breast Cancer Cells
P21 activated kinases (or group I PAKs) are serine/threonine kinases whose expression is altered in prostate and breast cancers. PAK-1 activity is inhibited by the small molecule “Inhibitor targeting PAK-1 activation-3” (IPA-3), which has selectivity for PAK-1 but is metabolically unstable. Secretor...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7764208/ https://ncbi.nlm.nih.gov/pubmed/33321758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249396 |
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