Sterically stabilized liposomes targeting P21 (RAC1) activated kinase-1 and secreted phospholipase A(2) suppress prostate cancer growth and metastasis

Metastatic prostate cancer (PCa) has a very high mortality rate in men, in Western countries and lacks reliable treatment. The advanced-stage PCa cells overexpress P21 (RAC1) activated kinase-1 (PAK1) and secreted phospholipase A(2) (sPLA(2)) suggesting the potential utility of pharmacologically tar...

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Veröffentlicht in:Oncol Lett
Hauptverfasser: Verma, Arti, Najahi-Missaoui, Wided, Cummings, Brian S., Somanath, Payaningal R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471734/
https://ncbi.nlm.nih.gov/pubmed/32934746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.12040
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