Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover

BACKGROUND: Cancer research, in general, is focused on targeting tumour cells to limit tumour growth. These studies, however, do not account for the specific effects of chemotherapy on tumour endothelium, in turn, affecting metastasis. METHODS: We determined how endothelial deletion of Akt1 promotes...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Gao, Fei, Alwhaibi, Abdulrahman, Artham, Sandeep, Verma, Arti, Somanath, Payaningal R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988746/
https://ncbi.nlm.nih.gov/pubmed/29755115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0110-1
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