Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover

BACKGROUND: Cancer research, in general, is focused on targeting tumour cells to limit tumour growth. These studies, however, do not account for the specific effects of chemotherapy on tumour endothelium, in turn, affecting metastasis. METHODS: We determined how endothelial deletion of Akt1 promotes...

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Опубликовано в: :Br J Cancer
Главные авторы: Gao, Fei, Alwhaibi, Abdulrahman, Artham, Sandeep, Verma, Arti, Somanath, Payaningal R.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988746/
https://ncbi.nlm.nih.gov/pubmed/29755115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0110-1
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