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Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover

BACKGROUND: Cancer research, in general, is focused on targeting tumour cells to limit tumour growth. These studies, however, do not account for the specific effects of chemotherapy on tumour endothelium, in turn, affecting metastasis. METHODS: We determined how endothelial deletion of Akt1 promotes...

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Detaylı Bibliyografya
Yayımlandı:Br J Cancer
Asıl Yazarlar: Gao, Fei, Alwhaibi, Abdulrahman, Artham, Sandeep, Verma, Arti, Somanath, Payaningal R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988746/
https://ncbi.nlm.nih.gov/pubmed/29755115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0110-1
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