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Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity

(1) Background: We characterized a novel animal model with obesity-induced constipation because constipation is rarely known in genetically engineered mice (GEM); (2) Methods: The changes in the constipation parameters and mechanisms were analyzed in CRISPR-Cas9-mediated leptin (Lep) knockout (KO) m...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kim, Ji Eun, Choi, Yun Ju, Lee, Su Jin, Gong, Jeong Eun, Lim, Yong, Hong, Jin Tae, Hwang, Dae Youn
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763920/
https://ncbi.nlm.nih.gov/pubmed/33322729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249464
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