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Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90

Inhibition of the molecular chaperone heat shock protein 90 (Hsp90) represents a promising approach for cancer treatment. BIIB021 is a highly potent Hsp90 inhibitor with remarkable anticancer activity; however, its clinical application is limited by lack of potency and response. In this study, we ai...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Mol Sci
Egile Nagusiak: Shin, Sang Chul, El-Damasy, Ashraf K., Lee, Ju Hyeon, Seo, Seon Hee, Kim, Ji Hyun, Seo, Young Ho, Lee, Yuri, Yu, Ji Hoon, Bang, Eun Kyoung, Kim, Eunice EunKyeong, Keum, Gyochang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763603/
https://ncbi.nlm.nih.gov/pubmed/33317068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249377
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