Alpha Ketoglutarate Exerts In Vitro Anti-Osteosarcoma Effects through Inhibition of Cell Proliferation, Induction of Apoptosis via the JNK and Caspase 9-Dependent Mechanism, and Suppression of TGF-β and VEGF Production and Metastatic Potential of Cells

Osteosarcoma (OS) is the most common type of primary bone tumor. Currently, there are limited treatment options for metastatic OS. Alpha-ketoglutarate (AKG), i.e., a multifunctional intermediate of the Krebs cycle, is one of the central metabolic regulators of tumor fate and plays an important role...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Kaławaj, Katarzyna, Sławińska-Brych, Adrianna, Mizerska-Kowalska, Magdalena, Żurek, Aleksandra, Bojarska-Junak, Agnieszka, Kandefer-Szerszeń, Martyna, Zdzisińska, Barbara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763003/
https://ncbi.nlm.nih.gov/pubmed/33321940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249406
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