N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation b...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sy, Michael, Brandt, Alexander U., Lee, Sung-Uk, Newton, Barbara L., Pawling, Judy, Golzar, Autreen, Rahman, Anas M. A., Yu, Zhaoxia, Cooper, Graham, Scheel, Michael, Paul, Friedemann, Dennis, James W., Demetriou, Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762951/
https://ncbi.nlm.nih.gov/pubmed/33453988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015595
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