The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in Parasite Protein Glycosylation

A gene encoding Trypanosoma brucei UDP-N-acetylglucosamine pyrophosphorylase was identified, and the recombinant protein was shown to have enzymatic activity. The parasite enzyme is unusual in having a strict substrate specificity for N-acetylglucosamine 1-phosphate and in being located inside a per...

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Detalhes bibliográficos
Main Authors: Stokes, Matthew J., Güther, M. Lucia S., Turnock, Daniel C., Prescott, Alan R., Martin, Kirstee L., Alphey, Magnus S., Ferguson, Michael A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2414269/
https://ncbi.nlm.nih.gov/pubmed/18381290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709581200
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