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Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion

In Alzheimer's disease (AD), tau, a microtubule-associated protein (MAP), becomes hyperphosphorylated, aggregates, and accumulates in the somato-dendritic compartment of neurons. In parallel to its intracellular accumulation in AD, tau is also released in the extracellular space, as revealed by...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Pilliod, Julie, Desjardins, Alexandre, Pernègre, Camille, Jamann, Hélène, Larochelle, Catherine, Fon, Edward A., Leclerc, Nicole
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762943/
https://ncbi.nlm.nih.gov/pubmed/33454017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013553
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