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Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion
In Alzheimer's disease (AD), tau, a microtubule-associated protein (MAP), becomes hyperphosphorylated, aggregates, and accumulates in the somato-dendritic compartment of neurons. In parallel to its intracellular accumulation in AD, tau is also released in the extracellular space, as revealed by...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7762943/ https://ncbi.nlm.nih.gov/pubmed/33454017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013553 |
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