Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance

Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium tuberculosis, has less than 1% of the catalytic efficiency of a typical na...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Fahrig-Kamarauskait≑, Jūrate˙, Würth-Roderer, Kathrin, Thorbjørnsrud, Helen V., Mailand, Susanne, Krengel, Ute, Kast, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762937/
https://ncbi.nlm.nih.gov/pubmed/33453995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014924
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