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Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance
Chorismate mutase (CM), an essential enzyme at the branch-point of the shikimate pathway, is required for the biosynthesis of phenylalanine and tyrosine in bacteria, archaea, plants, and fungi. MtCM, the CM from Mycobacterium tuberculosis, has less than 1% of the catalytic efficiency of a typical na...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7762937/ https://ncbi.nlm.nih.gov/pubmed/33453995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014924 |
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