Deleterious Effects of Hyperactivity of the Renin-Angiotensin System and Hypertension on the Course of Chemotherapy-Induced Heart Failure after Doxorubicin Administration: A Study in Ren-2 Transgenic Rat

Doxorubicin’s (DOX) cardiotoxicity contributes to the development of chemotherapy-induced heart failure (HF) and new treatment strategies are in high demand. The aim of the present study was to characterize a DOX-induced model of HF in Ren-2 transgenic rats (TGR), those characterized by hypertension...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kala, Petr, Bartušková, Hana, Piťha, Jan, Vaňourková, Zdenka, Kikerlová, Soňa, Jíchová, Šárka, Melenovský, Vojtěch, Hošková, Lenka, Veselka, Josef, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Gawrys, Olga, Maxová, Hana, Červenka, Luděk
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762559/
https://ncbi.nlm.nih.gov/pubmed/33302374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249337
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