Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Polyglutamine (polyQ)-mediated spinocerebellar ataxias (SCA) are caused by mutant genes with expanded CAG repeats encoding polyQ tracts. The misfolding and aggregation of polyQ proteins result in increased reactive oxygen species (ROS) and cellular toxicity. Inflammation is a common manifestation of...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Aging (Albany NY)
Päätekijät: Chiu, Ya-Jen, Lin, Shu-An, Chen, Wan-Ling, Lin, Te-Hsien, Lin, Chih-Hsin, Yao, Ching-Fa, Lin, Wenwei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals 2020
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762503/
https://ncbi.nlm.nih.gov/pubmed/33196459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103700
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