Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Polyglutamine (polyQ)-mediated spinocerebellar ataxias (SCA) are caused by mutant genes with expanded CAG repeats encoding polyQ tracts. The misfolding and aggregation of polyQ proteins result in increased reactive oxygen species (ROS) and cellular toxicity. Inflammation is a common manifestation of...

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Bibliografski detalji
Izdano u:Aging (Albany NY)
Glavni autori: Chiu, Ya-Jen, Lin, Shu-An, Chen, Wan-Ling, Lin, Te-Hsien, Lin, Chih-Hsin, Yao, Ching-Fa, Lin, Wenwei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals 2020
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762503/
https://ncbi.nlm.nih.gov/pubmed/33196459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103700
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