Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

Polyglutamine (polyQ)-mediated spinocerebellar ataxias (SCA) are caused by mutant genes with expanded CAG repeats encoding polyQ tracts. The misfolding and aggregation of polyQ proteins result in increased reactive oxygen species (ROS) and cellular toxicity. Inflammation is a common manifestation of...

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Dettagli Bibliografici
Pubblicato in:Aging (Albany NY)
Autori principali: Chiu, Ya-Jen, Lin, Shu-An, Chen, Wan-Ling, Lin, Te-Hsien, Lin, Chih-Hsin, Yao, Ching-Fa, Lin, Wenwei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals 2020
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762503/
https://ncbi.nlm.nih.gov/pubmed/33196459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103700
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