Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo

SIMPLE SUMMARY: Growth hormone (GH) action is strongly implicated in the progression and therapy resistance in several types of solid tumors which overexpress the GH receptor (GHR). The aim of our study was to characterize the effects of GH and its downstream effector insulin-like growth factor 1 (I...

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Udgivet i:Cancers (Basel)
Main Authors: Qian, Yanrong, Basu, Reetobrata, Mathes, Samuel C., Arnett, Nathan A., Duran-Ortiz, Silvana, Funk, Kevin R., Brittain, Alison L., Kulkarni, Prateek, Terry, Joseph C., Davis, Emily, Singerman, Jordyn T., Henry, Brooke E., List, Edward O., Berryman, Darlene E., Kopchick, John J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7761932/
https://ncbi.nlm.nih.gov/pubmed/33291663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123640
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