Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates

Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder with heterotopic ossification (HO) in soft tissues. The abnormal activation of bone morphogenetic protein (BMP) signaling by a mutant activin receptor-like kinase-2 (ALK2) leads to the development of HO in FOP patients, and, t...

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Bibliographic Details
Published in:Mar Drugs
Main Authors: Yamazaki, Hiroyuki, Ohte, Satoshi, Rotinsulu, Henki, Wewengkang, Defny S., Sumilat, Deiske A., Abdjul, Delfly B., Maarisit, Wilmar, Kapojos, Magie M., Namikoshi, Michio, Katagiri, Takenobu, Tomoda, Hiroshi, Uchida, Ryuji
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7761252/
https://ncbi.nlm.nih.gov/pubmed/33265937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md18120606
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