A polybromodiphenyl ether from an Indonesian marine sponge Lamellodysideaherbacea and its chemical derivatives inhibit protein tyrosine phosphatase 1B, an important target for diabetes treatment

The ethanol extract of an Indonesian marine sponge Lamellodysidea herbacea inhibited the activity of protein tyrosine phosphatase 1B (PTP1B), an important target enzyme for the treatment of type II diabetes. Bioassay-guided isolation yielded a known polybromodiphenyl ether (1) as a sole bioactive co...

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Autores principales: Yamazaki, Hiroyuki, Sumilat, Deiske A., Kanno, Syu-ichi, Ukai, Kazuyo, Rotinsulu, Henki, Wewengkang, Defny S., Ishikawa, Masaaki, Mangindaan, Remy E. P., Namikoshi, Michio
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Japan 2012
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765847/
https://ncbi.nlm.nih.gov/pubmed/23274914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11418-012-0735-y
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