Mutant Activin-Like Kinase 2 in Fibrodysplasia Ossificans Progressiva are Activated via T203 by BMP Type II Receptors

Fibrodysplasia ossificans progressiva (FOP) is a genetic disorder characterized by progressive heterotopic ossification in soft tissues, such as the skeletal muscles. FOP has been shown to be caused by gain-of-function mutations in activin receptor-like kinase (ALK)-2, which is a type I receptor for...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Fujimoto, Mai, Ohte, Satoshi, Osawa, Kenji, Miyamoto, Arei, Tsukamoto, Sho, Mizuta, Takato, Kokabu, Shoichiro, Suda, Naoto, Katagiri, Takenobu
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414771/
https://ncbi.nlm.nih.gov/pubmed/25354296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1301
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