Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

Glioblastoma is a severe type of brain tumor with a poor prognosis and few therapy options. Temozolomide (TMZ) is one of these options, however, with limited success, and failure is mainly due to tumor resistance. In this work, genome-wide CRISPR-Cas9 lentiviral screen libraries for gene knockout or...

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Vydáno v:Cells
Hlavní autoři: Ribeiro Reily Rocha, Clarissa, Reily Rocha, Alexandre, Molina Silva, Matheus, Rodrigues Gomes, Luciana, Teatin Latancia, Marcela, Andrade Tomaz, Marina, de Souza, Izadora, Karolynne Seregni Monteiro, Linda, Frederico Martins Menck, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7760831/
https://ncbi.nlm.nih.gov/pubmed/33271924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9122573
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