Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPR(ER) Activation and Behavior in C. elegans

In C. elegans, expression of the UPR(ER) transcription factor xbp-1s in neurons cell non-autonomously activates the UPR(ER) in the intestine, leading to enhanced proteostasis and lifespan. To better understand this signaling pathway, we isolated neurons from animals expressing neuronal xbp-1s for tr...

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Publicat a:Dev Cell
Autors principals: Özbey, Neşem P., Imanikia, Soudabeh, Krueger, Christel, Hardege, Iris, Morud, Julia, Sheng, Ming, Schafer, William R., Casanueva, M. Olivia, Taylor, Rebecca C.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758879/
https://ncbi.nlm.nih.gov/pubmed/33232669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.10.024
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