XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

Schmid metaphyseal chondrodysplasia (MCDS) involves dwarfism and growth plate cartilage hypertrophic zone expansion resulting from dominant mutations in the hypertrophic zone collagen, Col10a1. Mouse models phenocopying MCDS through the expression of an exogenous misfolding protein in the endoplasmi...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Cameron, Trevor L., Bell, Katrina M., Gresshoff, Irma L., Sampurno, Lisa, Mullan, Lorna, Ermann, Joerg, Glimcher, Laurie H., Boot-Handford, Raymond P., Bateman, John F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651170/
https://ncbi.nlm.nih.gov/pubmed/26372225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005505
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