XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease

The unfolded protein response (UPR) is a conserved cellular response to the accumulation of proteinaceous material in endoplasmic reticulum (ER), active both in health and disease to alleviate cellular stress and improve protein folding. Multiple epiphyseal dysplasia (EDM5) is a genetic skeletal con...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Piróg, Katarzyna A., Dennis, Ella P., Hartley, Claire L., Jackson, Robert M., Soul, Jamie, Schwartz, Jean-Marc, Bateman, John F., Boot-Handford, Raymond P., Briggs, Michael D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625722/
https://ncbi.nlm.nih.gov/pubmed/31260448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008215
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