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Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPR(ER) Activation and Behavior in C. elegans
In C. elegans, expression of the UPR(ER) transcription factor xbp-1s in neurons cell non-autonomously activates the UPR(ER) in the intestine, leading to enhanced proteostasis and lifespan. To better understand this signaling pathway, we isolated neurons from animals expressing neuronal xbp-1s for tr...
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| Publicado no: | Dev Cell |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7758879/ https://ncbi.nlm.nih.gov/pubmed/33232669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.10.024 |
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