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Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

G protein–coupled receptors (GPCRs) that couple to G(i/o) proteins modulate neurotransmission presynaptically by inhibiting exocytosis. Release of Gβγ subunits from activated G proteins decreases the activity of voltage-gated Ca(2+) channels (VGCCs), decreasing excitability. A less understood Gβγ−me...

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מידע ביבליוגרפי
הוצא לאור ב:	Sci Signal
Main Authors:	Zurawski, Zack, Gray, Analisa D. Thompson, Brady, Lillian J., Page, Brian, Church, Emily, Harris, Nicholas A., Dohn, Michael R., Yim, Yun Young, Hyde, Karren, Mortlock, Douglas P., Jones, Carrie K., Winder, Danny G., Alford, Simon, Hamm, Heidi E.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2019
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7758873/ https://ncbi.nlm.nih.gov/pubmed/30783011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat8595
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Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

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