Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

G protein–coupled receptors (GPCRs) that couple to G(i/o) proteins modulate neurotransmission presynaptically by inhibiting exocytosis. Release of Gβγ subunits from activated G proteins decreases the activity of voltage-gated Ca(2+) channels (VGCCs), decreasing excitability. A less understood Gβγ−me...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Zurawski, Zack, Gray, Analisa D. Thompson, Brady, Lillian J., Page, Brian, Church, Emily, Harris, Nicholas A., Dohn, Michael R., Yim, Yun Young, Hyde, Karren, Mortlock, Douglas P., Jones, Carrie K., Winder, Danny G., Alford, Simon, Hamm, Heidi E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758873/
https://ncbi.nlm.nih.gov/pubmed/30783011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat8595
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