Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

G protein–coupled receptors (GPCRs) that couple to G(i/o) proteins modulate neurotransmission presynaptically by inhibiting exocytosis. Release of Gβγ subunits from activated G proteins decreases the activity of voltage-gated Ca(2+) channels (VGCCs), decreasing excitability. A less understood Gβγ−me...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Signal
Päätekijät: Zurawski, Zack, Gray, Analisa D. Thompson, Brady, Lillian J., Page, Brian, Church, Emily, Harris, Nicholas A., Dohn, Michael R., Yim, Yun Young, Hyde, Karren, Mortlock, Douglas P., Jones, Carrie K., Winder, Danny G., Alford, Simon, Hamm, Heidi E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758873/
https://ncbi.nlm.nih.gov/pubmed/30783011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat8595
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