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Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes
G protein–coupled receptors (GPCRs) that couple to G(i/o) proteins modulate neurotransmission presynaptically by inhibiting exocytosis. Release of Gβγ subunits from activated G proteins decreases the activity of voltage-gated Ca(2+) channels (VGCCs), decreasing excitability. A less understood Gβγ−me...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Signal |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7758873/ https://ncbi.nlm.nih.gov/pubmed/30783011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat8595 |
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