Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

G protein–coupled receptors (GPCRs) that couple to G(i/o) proteins modulate neurotransmission presynaptically by inhibiting exocytosis. Release of Gβγ subunits from activated G proteins decreases the activity of voltage-gated Ca(2+) channels (VGCCs), decreasing excitability. A less understood Gβγ−me...

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Udgivet i:Sci Signal
Main Authors: Zurawski, Zack, Gray, Analisa D. Thompson, Brady, Lillian J., Page, Brian, Church, Emily, Harris, Nicholas A., Dohn, Michael R., Yim, Yun Young, Hyde, Karren, Mortlock, Douglas P., Jones, Carrie K., Winder, Danny G., Alford, Simon, Hamm, Heidi E.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758873/
https://ncbi.nlm.nih.gov/pubmed/30783011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat8595
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