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Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma

BACKGROUND: Intratumor heterogeneity (ITH) has been shown to be inversely associated with immune infiltration in several cancers including clear cell renal cell carcinoma (ccRCC), but it remains unclear whether ITH is associated with response to immunotherapy (e.g. PD-1 blockade) in ccRCC. METHODS:...

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Detalhes bibliográficos
Publicado no:Ther Adv Med Oncol
Main Authors: Ran, Xia, Xiao, Jinyuan, Zhang, Yi, Teng, Huajing, Cheng, Fang, Chen, Huiqian, Zhang, Kaifan, Sun, Zhongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758866/
https://ncbi.nlm.nih.gov/pubmed/33425025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920977117
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