Low intratumor heterogeneity correlates with increased response to PD-1 blockade in renal cell carcinoma

BACKGROUND: Intratumor heterogeneity (ITH) has been shown to be inversely associated with immune infiltration in several cancers including clear cell renal cell carcinoma (ccRCC), but it remains unclear whether ITH is associated with response to immunotherapy (e.g. PD-1 blockade) in ccRCC. METHODS:...

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Vydáno v:Ther Adv Med Oncol
Hlavní autoři: Ran, Xia, Xiao, Jinyuan, Zhang, Yi, Teng, Huajing, Cheng, Fang, Chen, Huiqian, Zhang, Kaifan, Sun, Zhongsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758866/
https://ncbi.nlm.nih.gov/pubmed/33425025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920977117
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