Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats

Viral-mediated gene augmentation offers tremendous promise for the treatment of inherited retinal diseases. The development of effective gene therapy requires an understanding of the vector's tissue-specific behavior, which may vary depending on serotype, route of delivery, or target species. U...

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Udgivet i:Hum Gene Ther
Main Authors: Han, Ian C., Cheng, Justine L., Burnight, Erin R., Ralston, Christy L., Fick, Jessica L., Thomsen, Gabriella J., Tovar, Emilio F., Russell, Stephen R., Sohn, Elliott H., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A., Wiley, Luke A.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc., publishers 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757705/
https://ncbi.nlm.nih.gov/pubmed/32948113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.043
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