Retinal Tropism and Transduction of Adeno-Associated Virus Varies by Serotype and Route of Delivery (Intravitreal, Subretinal, or Suprachoroidal) in Rats

Viral-mediated gene augmentation offers tremendous promise for the treatment of inherited retinal diseases. The development of effective gene therapy requires an understanding of the vector's tissue-specific behavior, which may vary depending on serotype, route of delivery, or target species. U...

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Detalles Bibliográficos
Publicado en:Hum Gene Ther
Main Authors: Han, Ian C., Cheng, Justine L., Burnight, Erin R., Ralston, Christy L., Fick, Jessica L., Thomsen, Gabriella J., Tovar, Emilio F., Russell, Stephen R., Sohn, Elliott H., Mullins, Robert F., Stone, Edwin M., Tucker, Budd A., Wiley, Luke A.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757705/
https://ncbi.nlm.nih.gov/pubmed/32948113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.043
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